Recent research has shown that a cautious "injury" (also called "priming") of the endometrium in the cycle before in vitro fertilization may increase the chance of pregnancy and childbirth.
It is not known if endometrial priming increases the chances of pregnancy in all women.
We suggest that endometrial priming is considered if there have been embryos of good quality two or more times without having achieved pregnancy.
Endometrial priming made about a week before the expected menstruation cycle before IVF treatment.
Treatment consists of a very careful and superficial scraping with a 2 mm thin plastic tube for 5-10 seconds. The procedure may induce a slight menstrual-like pain.
The Cochrane Library is an independent international organisation that evaluates the scientific evidence for many types of treatment. In the most recent review of endometrial priming the conclusion is:
Endometrial "injury" performed prior to the embryo transfer cycle improves clinical pregnancy and live birth rates in women undergoing ART. It is advisable not to perform endometrial injury on the day of oocyte retrieval because it appears to significantly reduce clinical and ongoing pregnancy rates. There is insufficient evidence regarding the effect of endometrial injury on multiple pregnancy or miscarriage and none on adverse events such as pain and bleeding.
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